Anti-Human Muscle Acetylcholine Receptor mAbs [mAb 192](MABL-1908)

Cat. No.

MABL-1908

Name

Anti-Human Muscle Acetylcholine Receptor mAbs

Clone No.

AFD- mAb 192

From

Recombinant Antibody

Isotype

Engineer antibody

Application

Blocking, WB, ELISA

Species Reactivity

Rat, Human, Mouse

Basic Information

Specificity

The antibody binds to human muscle AChR with   a Kd of 10 pM, to mouse muscle AChR with a Kd of 50 pM, and to rat muscle   AChR with a Kd of 646 nM.

Alternative Name

AChR

UniProt

P02708 (For the alpha-subunit)

Immunogen

Human muscle AChR.

Application Notes

This antibody binds to the human muscle   Acetylcholine receptor, which is a ligand- gated ion channel, transducing an   action potential into the muscle cells. The antibody binds to the main   immunogenic region (MIR) and prevents ligand-binding.

Antibody First   Published

Kontou et al. Characterisation,   crystallisation and preliminary X-ray diffraction analysis of a Fab fragment   of a rat monoclonal antibody with very high affinity for the human muscle   acetylcholine receptor. FEBS Letters 1996; 389(2):195-198 PMID:8766828

Note on publication

Describes the generation of a super-high-affinity rat antibody against human muscle AChR and subsequent crystallography

COA Information （For reference only, actual COA shall prevail）

Size

100 μg Purified   antibody.

Concentration

1 mg/ml.

Purification

Protein A affinity   purified

Buffer

PBS with 0.02% Proclin   300.

Concentration

1 mg/ml.

Storage   Recommendation

Store at 4⁰C for up to 3   months. For longer storage, aliquot and store at - 20⁰C.