Key features and details | |
Cat. No. | MABL-1135 |
Name | Anti-CD81 mAbs |
Clone No. | AFD- 1D6 |
From | Recombinant Antibody |
Isotype | Engineer antibody |
Application | functional, ICC/IF, IHC-P, IP, WB, ELISA, FC |
Species Reactivity | Human, Chimpanzee, Goat, Sheep |
Basic Information | |
Specificity | This antibody is specific for human CD81, which is expressed on most tissues with the exception of red blood cells and platelets. |
Alternative Name | Tetraspanin-28; TAPA-1; Target of the Antiproliferative Antibody 1; Tspan-28 |
UniProt | P60033 |
Immunogen | This antibody was produced by immunizing mice with 5A6-aggregated OCI-LY8 B cells. |
Application Notes | This antibody is a strong inducer of homotypic adhesion in hematolymphoid cells (Levy, 1998). This antibody also has an anti-proliferative effect, and is able to induce growth inhibition of B cell lines. Triggering of CD81 by this antibody induces a significant upregulation of the constituitive release of TNF-α by JY cells, an Eptsein-Barr virus-positive B lymphoblastoid cell line (Altomonte, 1995). |
Antibody First Published | Levy et al. CD81 (TAPA-1)： a molecule involved in signal transduction and cell adhesion in the immune system Annual review of immunology, 1998, Vol.16, pp.89-109 [Peer Reviewed Journal] PMID：9597125 |
Note on publication | Describes the original production of this antibody, and its use in characterising the CD81 antigen. |
COA Information （For reference only, actual COA shall prevail） | |
Size | 100 μg Purified antibody. |
Concentration | 1 mg/ml. |
Purification | Protein A affinity purified |
Buffer | PBS with 0.02% Proclin 300. |
Concentration | 1 mg/ml. |
Storage Recommendation | Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at - 20⁰C. |
