Key features and details | |
Cat. No. | MABL-1056 |
Name | Anti-CD62L mAbs |
Clone No. | AFD- DREG-56 |
From | Recombinant Antibody |
Isotype | Engineer antibody |
Application | Blocking, IP, WB, FC |
Species Reactivity | Human, Chimpanzee, Bovine |
Basic Information | |
Specificity | This antibody is specific for human L-selectin, a homing receptor selectively expressed on lymphocytes, which allows their entry into secondary lymphoid tissues via high endothelial venules. |
Alternative Name | L-selectin; LECAM-1; Ly-22; MEL-14; CD62 antigen-like family member L; Leukocyte adhesion molecule 1; LAM-1; Leukocyte-endothelial cell adhesion molecule 1; LECAM1; Lymph node homing receptor; Lymphocyte antigen 22; Lymphocyte surface MEL-14 antigen |
UniProt | P14151 |
Immunogen | This antibody was produced by immunizing mice with the concentrated supernatant generated after centrifugation of human peripheral blood leukocytes. |
Application Notes | This antibody has been used in WB, IP and binding assays to define a lymphocyte homing receptor for PLN HEVs (Kishimoto, 1990). In vitro, this antibody has been shown to specifically inhibit over 90% of binding of human lymphocytes to HEVs within frozen sections of peripheral, but not mucosal, lymphoid tissue (Kishimoto, 1990). This antibody has also been used in labelling studies to demonstate that the trophectoderm of implantation-competent human embryos expresses L-selectin (Genbacev, 2003). |
Antibody First Published | Kishimoto et al. Identification of a Human Peripheral Lymph Node Homing Receptor: A Rapidly Down-Regulated Adhesion Molecule Proceedings of the National Academy of Sciences of the United States of America, 1 March 1990, Vol.87(6), pp.2244-2248 PMID:2179952 |
Note on publication | Describes the original use of this antibody, along with others, to define a lymphocyte homing receptor (L-selectin). |
COA Information （For reference only, actual COA shall prevail） | |
Size | 100 μg Purified antibody. |
Concentration | 1 mg/ml. |
Purification | Protein A affinity purified |
Buffer | PBS with 0.02% Proclin 300. |
Concentration | 1 mg/ml. |
Storage Recommendation | Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at - 20⁰C. |
