Anti-CD55 mAbs

Cat. No.

MABL-1039

Name

Anti-CD55 mAbs

Clone No.

AFD- LU30

From

Recombinant Antibody

Isotype

Engineer antibody

Application

WB, ELISA, IHC

Species Reactivity

Human

Basic Information

Specificity

 The antibody binds to CD55 with a Kd of 13   nM.

Alternative Name

 DAF; Complement decay-accelerating factor

UniProt

 P08174

Immunogen

 Human CD55.

Application Notes

The antibody binds specifically to CD55, a glycophosphatidylinositol-anchored   protein which acts together with CD46 and CD59 to protect cells from   complement-mediated cell lysis. The antigen recognises C4b, C3 and C3b   complement components, and, by blocking their catalytic activity, inhibits   the formation of the membrane attack complex. CD55 is overexpressed in many   tumour cell lines, thereby inhibiting complement-mediated cell lysis and   increases tumour resistance to immune attacks.

Antibody First Published

Ridgway,J.B., Ng,E., Kern,J.A., Lee,J.,   Brush,J., Goddard,A. and Carter,P. Identification of a human anti-CD55   single-chain Fv by subtractive panning of a phage library using tumor and   nontumor cell lines. Cancer Res. 59 (11), 2718-2723 (1999) PMID:10363997

Note on publication

Describes the use of a human single-chain Fv   phage library to search tumor- associated antigens and the production of   monoclonal antibodies against the antigens.

COA Information （For reference only, actual COA shall prevail）

Size

100 μg Purified antibody.

Concentration

1 mg/ml.

Purification

Protein A affinity purified

Buffer

PBS with 0.02% Proclin 300.

Concentration

1 mg/ml.

Storage Recommendation

Store at 4⁰C for up to 3 months. For   longer storage, aliquot and store at - 20⁰C.