Key features and details | |
Cat. No. | MABL-975 |
Name | Anti-CD44v6 mAbs |
Clone No. | AFD- BIWA8 |
From | Recombinant Antibody |
Isotype | Engineer antibody |
Application | in vivo |
Species Reactivity | Human |
Basic Information | |
Specificity | The antibody is specific for CD44v6. CD44v6 is a tumor associated antigen abundantly expressed in head and neck squamous cell carcinomas (HNSCC) and in normal squamous epithelium. |
Alternative Name | CD44 antigen; CDw44; Epican; Extracellular matrix receptor III; ECMR-III; GP90 lymphocyte homing/adhesion receptor; HUTCH-I; Heparan sulfate proteoglycan; Hermes antigen; Hyaluronate receptor; Phagocytic glycoprotein 1; PGP-1; Phagocytic glycoprotein I; PGP-I |
UniProt | P16070 |
Immunogen | The antibody is the humanized version of the murine BIWA-1. |
Application Notes | The antibody is the mutated version of BIWA-4 that was constructed with the aim of improving binding affinity. The binding affinity of the antibody to CD44v6 was measured by surface plasmon resonance. The antibody showed a specificity of tumor localization when administrated together with another anti-CD44v6 antibody to mice in in vivo experiments (Verel et al. 2002; PMID: 11992408). The specificity of the humanized version of the antibody was confirmed by ELISA anlaysis (Kd= 0.84 nM). The antibody had good therapeutic efficacy in in vivo experiments in mice. Mice treated with labelled 186Re- BIWA 8 showed a decreased in the tumor volume (US6972324B2). |
Antibody First Published | |
Note on publication | |
COA Information （For reference only, actual COA shall prevail） | |
Size | 100 μg Purified antibody. |
Concentration | 1 mg/ml. |
Purification | Protein A affinity purified |
Buffer | PBS with 0.02% Proclin 300. |
Concentration | 1 mg/ml. |
Storage Recommendation | Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at - 20⁰C. |
