Key features and details | |
Cat. No. | MABL-958 |
Name | Anti-CD43 mAbs |
Clone No. | AFD- L11 |
From | Recombinant Antibody |
Isotype | Engineer antibody |
Application | immunotherapy, Block, FC, IHC |
Species Reactivity | Mouse |
Basic Information | |
Specificity | L11 antibody binds specifically to mouse CD43. CD43 plays a role in the physicochemical properties of the T-cell surface and in lectin binding. CD43 is a major cell-surface sialoglycoprotein - also found on neutrophils, bone marrow stem cells, B-lineage cells after activation of thymocytes and T lymphocytes but is not expressed on resting B lymphocytes. The protein presents carbohydrate ligands to selectins and Is a counter-receptor for SN/Siglec-1. During T-cell activation it is actively removed from the T- cell-APC (antigen-presenting cell) contact site thus suggesting a negative regulatory role in adaptive immune response. |
Alternative Name | gpL115; leukosialin; sialophorin; L-11; Spn; Ly-48; Ly48; B-cell differentiation antigen LP-3; B-cell differentiation antigen LP3; Leukocyte sialoglycoprotein; CD-43 |
UniProt | P15702 |
Immunogen | L11 antibody was prepared by immunizing rats with mouse CD43. |
Application Notes | L11 has been shown to prevent the deveopment of diabetes in mice and has also been used for FC, IHC and to block the migration of T cells from the bloodstream into organized lymphoid tissues. L11 was also shown to inhibit the development of inflammation in pancreatic islets and salivary glands. |
Antibody First Published | Johnson GG et al. Anti-CD43 Monoclonal Antibody L11 Blocks Migration of T Cells to Inflamed Pancreatic Islets and Prevents Development of Diabetes in Nonobese Diabetic Mice J Immunol. 1999 Nov 15;163(10):5678-85. PMID:10553098 |
Note on publication | Shows that L11 blocks the migration of T cells from the bloodstream into inflamed pancreatic islets and salivary gland in the NOD (non-obese diabetic) mouse and its effectiveness in preventing diabetes in mice. |
COA Information （For reference only, actual COA shall prevail） | |
Size | 100 μg Purified antibody. |
Concentration | 1 mg/ml. |
Purification | Protein A affinity purified |
Buffer | PBS with 0.02% Proclin 300. |
Concentration | 1 mg/ml. |
Storage Recommendation | Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at - 20⁰C. |
