Cat. No.
MABL-1876
Application
WB, IHC
Isotype
Engineer antibody
Species Reactivity
Human
Clone No.
GLC82C238
From
Recombinant Antibody
Specificity
This antibody binds human heterogeneous nuclear ribonucleoproteins A2/B1 (hnRNP A2/B1). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. hnRNPA2/B1 is expressed during proliferation and metastasis of various cancer types and promotes such processes.
Alternative Names
Heterogeneous nuclear ribonucleoproteins A2/B1; HNRNPA2B1; RNPA2; HNRPA2; HNRPB1; SNRPB1; HNRNPA2; HNRNPB1; IBMPFD2; HNRPA2B1
UniProt
P22626
Immunogen
The original antibody was generated by immunizing BALB/ mice in the abdominal cavity with human lung cancer cell line GLC82.
Application Notes
This antibody was used in the immunohistochemical analysis of hnRNP A2/B1 expressed in lung squamous cell carcinoma, alveolar cancer and lung adenocarcinoma tissues. The binding of this antibody to HnRNP A2/B1 antigen was confirmed using western blotting (CN1273489).
Antibody First Published
Note on publication
Size
100 μg Purified antibody.
Concentration
1 mg/ml.
Purification
Protein A affinity purified
Buffer
PBS with 0.02% Proclin 300.
Storage Recommendation
Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at - 20⁰C.
