Key features and details | |
Cat. No. | MABL-906 |
Name | Anti-CD38 mAbs |
Clone No. | AFD- AT13/5 |
From | Recombinant Antibody |
Isotype | Engineer antibody |
Application | FC |
Species Reactivity | Human |
Basic Information | |
Specificity | Binds specifically to human CD38, an approximately 45 kDa type II transmembrane protein, expressed on essentially all pre-B lymphocytes, plasma cells, and thymocytes. Also present on activated T lymphocytes, natural killer (NK) lymphocytes, myeloblasts, and erythroblasts. Bimodally expressed during B cell development, modulating from high in immature cells to low in intermediate ones and back to high on mature B cells. This antibody competes with clone HB7 (Ab00128) (Ellis 1995) which has been shon to bind to an epitope between amino acids 273-285). |
Alternative Name | ADP-ribosyl cyclase 1; cyclic ADP-ribose hydrolase; EC 3.2.2.5; Cyclic ADP-ribose hydrolase 1; cADPr hydrolase 1; T10; CD38; p45; NAD(+) nucleosidase |
UniProt | P28907 |
Immunogen | Namalwa cells emulsified in CFA. |
Application Notes | The antibody binds to CD38, a glycoportein on the surface of various immune cells that catalyzes the hydrolysis of cyclic ADP-ribose to NAD+ and ADP-ribose. |
Antibody First Published | Ellis et al Engineered anti-CD38 monoclonal antibdies for immunotherapy of multiple myeloma. Journal of Immunology PMID:7608568 |
Note on publication | Describes the generation of murine monoclonal antibodies against CD38 and its potential use in therapy of multiple myeloma. |
COA Information （For reference only, actual COA shall prevail） | |
Size | 100 μg Purified antibody. |
Concentration | 1 mg/ml. |
Purification | Protein A affinity purified |
Buffer | PBS with 0.02% Proclin 300. |
Concentration | 1 mg/ml. |
Storage Recommendation | Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at - 20⁰C. |
