Anti-CD37 mAbs

Cat. No.

MABL-902

Name

Anti-CD37 mAbs

Clone No.

AFD- MB-1

From

Recombinant Antibody

Isotype

Engineer antibody

Application

ICC/IF, IHC-P, WB, FC

Species Reactivity

Human

Basic Information

Specificity

This antibody is specific for human CD37,   which is expressed on virtually all mature B lymphocytes, but not on pro-B or  plasma cells. CD37 is highly expressed on all forms of B cell non-Hodgkin   lymphoma, chronic lymphocyte leukemia, and other leukemias. CD37 does not   appear to be expressed on T cells, thymocytes, granulocytes or platelets.

Alternative Name

Tetraspanin-26; Tspan-26; Leukocyte antigen   CD37;

UniProt

P11049

Immunogen

BALB/c mice were immunized with lymph node   cells from a patient with nodular poorly differentiated lymphocytic lymphoma.   Immunophenotyping studies of these cells identified them as B cells   expressing SIgG/λ, as well as HLA-DR. Leu-12, and B1.

Application Notes

This antibody recognizes human CD37, and has   been used to identify and characterise the CD37 antigen in cell labelling,  indirect immunofluorescence and IP analysis (Link, 1986). In particular, the  use of this antibody to label malignant B cells indicates that expression of   CD37 occurs relatively late in B cell maturation, as it is not expressed on   "immature" B lineage lymphoid neoplasms.

Antibody First Published

Link et al. A unique antigen on mature B   cells defined by a monoclonal antibody. J Immunol. 1986 Nov 1;137(9):3013-8.  PMID:3489782

Note on publication

Describes the original use of this antibody   to identify a novel B cell antigen (CD37)

COA Information （For reference only, actual COA shall prevail）

Size

100 μg Purified antibody.

Concentration

1 mg/ml.

Purification

Protein A affinity purified

Buffer

PBS with 0.02% Proclin 300.

Concentration

1 mg/ml.

Storage Recommendation

Store at 4⁰C for up to 3 months. For   longer storage, aliquot and store at - 20⁰C.