Cat. No.
MABL-1051
Application
FC
Isotype
Engineer antibody
Species Reactivity
Human
Clone No.
OX-126
From
Recombinant Antibody
Specificity
This antibody is specific for the domain 2 of human CD6. Binding depends on a SNP ( R, amino acid 225).
Alternative Names
TP120; OX126; MRC OX-126; MRC OX 126
UniProt
P30203
Immunogen
This antibody was raised by immunizing BALB/c mice with a fusion protein consisting of human CD6 domain 3 and rat CD4 domains 3 and 4 (CD6d3CD4d3 + 4) (corrected, see: (Hassan et al., 2019; pmid: 30890626)).
Application Notes
This antibody is noncompetitive with OX125 and does not block CD6/CD166 interactions (Santos et al., 2019; pmid: 31162836).
Antibody First Published
Hassan et al. CD6 Regulates T-Cell Responses through Activation-Dependent Recruitment of the Positive Regulator SLP-76 MOLECULAR AND CELLULAR BIOLOGY, Sept. 2006, p.6727–6738 PMID:16914752
Note on publication
Describes the original use of this antibody to engage human CD6, blocking the CD6/CD166 interaction.
Size
100 μg Purified antibody.
Concentration
1 mg/ml.
Purification
Protein A affinity purified
Buffer
PBS with 0.02% Proclin 300.
Storage Recommendation
Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at - 20⁰C.
