Key features and details | |
Cat. No. | MABL-842 |
Name | Anti-CD26 mAbs |
Clone No. | AFD- OX-61 |
From | Recombinant Antibody |
Isotype | Engineer antibody |
Application | ICC, IP, RIA, WB, FC, IF, IHC |
Species Reactivity | Rat |
Basic Information | |
Specificity | OX-61 binds specifically to DPP4. Evidence： tissue distribution of OX-61 and DPP4 are identical; equal MWTs; OX-61-mediated reduction in DPP4 activity from solubilized liver homogenates. DPP4 is a glycoprotein receptor which acts as a positive regulator of T cell co-activation. |
Alternative Name | DPP4; DPP 4; DPPIV; DPP IV; Dipeptidyl peptidase 4; Bile canaliculus domain-specific membrane glycoprotein; GP110 glycoprotein; T-cell activation antigen CD26 ;OX61; MRC OX-61; MRC OX61 |
UniProt | P14740 |
Immunogen | OX-61 was prepared by immunizing mice with rat thoracic duct lymphoid cells that were enriched for dendritic cells. |
Application Notes | This antibody can be used for denaturing and non-denaturing WB and developed using peroxidase-conjugated rabbit anti-mouse. It can also be used for IHC of cryostat sections from adult rat liver. Staining is also observed on the brush border of the small intestine and colonic epithelium, T cell areas of lymphoid cells but not B cell follicles |
Antibody First Published | Paterson et al. Antigens of activated rat T lymphocytes including a molecule of 50,000 Mr detected only on CD4 positive T blasts. Mol Immunol 24：1281 1987 |
Note on publication | Describes the use of Ox-48 among other anitbodies to identify new markers for activated T-cells, which might have expression related to theactive Vs quiescient state or may be involved in specific T-cell functions. |
COA Information （For reference only, actual COA shall prevail） | |
Size | 100 μg Purified antibody. |
Concentration | 1 mg/ml. |
Purification | Protein A affinity purified |
Buffer | PBS with 0.02% Proclin 300. |
Concentration | 1 mg/ml. |
Storage Recommendation | Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at - 20⁰C. |
