Cat. No.
MABL-876
Application
Activating, ELISA, FC
Isotype
Engineer antibody
Species Reactivity
Human, Mouse
Clone No.
YMSM636
From
Recombinant Antibody
Specificity
This antibody recognises CD30 which is a receptor for TNFSF8/CD30L. It is thought to regulate cellular growth and lymphocytes development as well as gene expression via NF-kappa-B.
Alternative Names
TNFRSF8; YMSM 636.4.10; YMSM636; Tumor necrosis factor receptor superfamily member 8; CD30L receptor; Lymphocyte activation antigen CD30; Tnfrsf8
UniProt
Q60846
Immunogen
This antibody was raised by immunising rats with a mouse CD30 - human IgG1 fusion protein.
Application Notes
This antibody can be used to initiate apoptosis in isolated human peripheral blood eosinophils and thus it might be researched as a potential agent for therapeutic agents for hypereosinophilic diseases useful in the treatment of allergic diseases, respiratory diseases, skin diseases, autoimmune diseases, immunodeficiency diseases, digestive diseases, neoplastic diseases and parasitic infections (US20040156847A1).
Antibody First Published
Miura et al. Remedies for eosinophilic diseases US20040156847A1
Note on publication
This patent describes the application of this antibody in the apoptosis initation in eosinophiles.
Size
100 μg Purified antibody.
Concentration
1 mg/ml.
Purification
Protein A affinity purified
Buffer
PBS with 0.02% Proclin 300.
Storage Recommendation
Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at - 20⁰C.
