Cat. No.
MABL-815
Application
ELISA, FC
Isotype
Engineer antibody
Species Reactivity
Human
Clone No.
DN12
From
Recombinant Antibody
Specificity
This antibody binds human CD226. This protein is expressed on the surface of natural killer cells, platelets, monocytes and a subset of T cells. It is involved in intercellular adhesion, lymphocyte signaling, cytotoxicity and lymphokine secretion mediated by cytotoxic T-lymphocyte (CTL) and NK cell. It acts as cell surface receptor for NECTIN2. On binding with ligand it stimulates T-cell proliferation and cytokine production, including that of IL2, IL5, IL10, IL13, and IFNG.
Alternative Names
DNAM1; DNAM-1; TLisA1; PTA-1; CD226 antigen; DNAX accessory molecule 1; T lineage specific activation antigen 1; platelet and T cell antigen 1
UniProt
Q15762
Immunogen
The original antibody was generated by immunizing 4-6 weeks old female SPF or BALB/c mice with human DNAM-1 commercial antigen.
Application Notes
The binding characterization of this antibody to human CD226 was done using ELISA. This antibody was used for the detection of CD226 expressed on Jurkat cells using flow cytometry (CN112940122).
Antibody First Published
Note on publication
Size
100 μg Purified antibody.
Concentration
1 mg/ml.
Purification
Protein A affinity purified
Buffer
PBS with 0.02% Proclin 300.
Storage Recommendation
Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at - 20⁰C.
