Key features and details | |
Cat. No. | MABL-822 |
Name | Anti-CD23 mAbs |
Clone No. | AFD- IDEC-152 (Lumiliximab, 6G5) |
From | Recombinant Antibody |
Isotype | Engineer antibody |
Application | FC, Therapeutic, IP |
Species Reactivity | Human |
Basic Information | |
Specificity | This antibody is specific for human CD23. |
Alternative Name | Gomiliximab; FCER2; BLAST-2; FcεRII; Fc-epsilon-RII; Low affinity immunoglobulin epsilon Fc receptor; C-type lectin domain family 4 member J; Immunoglobulin E-binding factor; Lymphocyte IgE receptor |
UniProt | P06734 |
Immunogen | The original chimeric antibody was generated from a monkey immunized with human CD23. Later on the chimeric version of the antibody was generated by cloning the variable regions of the antibody into human constant regions. |
Application Notes | This antibody is also known as Gomiliximab. It binds CD23 or FCER2, a membrane protein and a "low affinity" receptor for IgE. It is also involved in IgE regulation and inflammation in allergic disorders, such as allergic rhinitis and allergic asthma. Phase I clinical trials in patients with allergic asthma revealed that IDEC-152 is safe and well-tolerated (PMID: 13679816). This antibody is also reported to have antitumor activity against chronic lymphocytic leukemia (CLL) in clinical trials (Woodworth et al., 2004; Byrd et al., 2004). Phase 1 study of Lumiliximab in patients with relapsed or refractory chronic lymphocytic leukemia reported that it was well tolerated and had clinical activity in patients. Flow cytometric analyses of blood samples were conducted to assess changes in lymphocyte subsets and to study both CD23 expression and binding of lumiliximab during the treatment (PMID: 17671129). |
Antibody First Published | Rosenwasser et al. Allergic asthma and an anti-CD23 mAb (IDEC-152): results of a phase I, single-dose, dose-escalating clinical trial. J Allergy Clin Immunol. (2003); 112(3):563-70. PMID:13679816 |
Note on publication | Describes the potential use of this antibody in the treatment of allergic asthma. |
COA Information （For reference only, actual COA shall prevail） | |
Size | 100 μg Purified antibody. |
Concentration | 1 mg/ml. |
Purification | Protein A affinity purified |
Buffer | PBS with 0.02% Proclin 300. |
Concentration | 1 mg/ml. |
Storage Recommendation | Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at - 20⁰C. |
