Cat. No.
MABL-744
Application
IHC
Isotype
Engineer antibody
Species Reactivity
Mouse
Clone No.
SER-4 (recombinant version)
From
Recombinant Antibody
Specificity
This antibody specifically recognize mouse CD169, which is a 180-185-kDa member of the Siglec family of macrophage-specific cell adhesion and endocytic receptors interacting with sialylated glycans. This receptor is expressed on a subset of macrophages that are found with high frequency in the spleen, liver, lymph node, and bone marrow. CD169 can also be detected on monocytes in the bone marrow and periphery.
Alternative Names
Sialoadhesin; Sheep erythrocyte receptor; SER; Sialic acid-binding Ig-like lectin 1; Siglec-1
UniProt
Q62230
Immunogen
Spleen cells from AO rats immunised with thioglycollate-elicted murine peritoneal macrophages (TPM) that had been cutured in mouse serum to induce sheep erythrocyte receptor (SER).
Application Notes
Antibody First Published
Crocker PR, Gordon S. Mouse macrophage hemagglutinin (sheep erythrocyte receptor) with specificity for sialylated glycoconjugates characterized by a monoclonal antibody. J Exp Med. 1989 Apr 1;169(4)：1333-46. PMID：2926328
Note on publication
Describes the making of SER-4 monoclonal antibody and characterizes the molecular nature and distribution on macrophage of SER with mAb SER-4 - inc data on IHC-Fr, IP and WB assays.
Size
100 μg Purified antibody.
Concentration
1 mg/ml.
Purification
Protein A affinity purified
Buffer
PBS with 0.02% Proclin 300.
Storage Recommendation
Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at - 20⁰C.
