Cat. No.
MABL-649
Application
antagonist, ELISA, FC
Isotype
Engineer antibody
Species Reactivity
Human
Clone No.
4.9000000000000004
From
Recombinant Antibody
Specificity
This antibody specifically binds an epitope located within the 2nd extracellular loop of human CCR2. The human C-C chemokine receptor type 2 is a key functional receptor for CCL2 but can also bind CCL7 and CCL12.
Alternative Names
CD192; C-C chemokine receptor type 2; C-C CKR-2; CC-CKR-2; CCR-2; Monocyte chemoattractant protein 1 receptor; MCP-1-R; CMKBR2; 4.9.2
UniProt
P41597
Immunogen
The original antibody was generated by immunizing human immunoglobulin generating XENOMOUSE™ mice with human CCR2 antigen.
Application Notes
The binding specificity of this antibody to full length CCR2, and 1St and 2nd loop of CCR2 was determined using ELISA. The binding reactivity of this antibody to the surface bound CCR2 receptors was confirmed with flow cytometry. This antibody can positively inhibit chemotaxis of THP-1 monocytes. The therapeutic effects of this antibody were studied in in vivo mouse models of inflammation, multiple sclerosis and neuropathic pain (US8710191).
Antibody First Published
Note on publication
Size
100 μg Purified antibody.
Concentration
1 mg/ml.
Purification
Protein A affinity purified
Buffer
PBS with 0.02% Proclin 300.
Storage Recommendation
Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at - 20⁰C.
