Cat. No.
MABL-527
Application
Blocking, SPR, ELISA
Isotype
Engineer antibody
Species Reactivity
Human
Clone No.
AbD1556
From
Recombinant Antibody
Specificity
The antibody binds to human BMPR-IA with a low nanomolar affinity.
Alternative Names
BMPR-IA
UniProt
P36894
Immunogen
Biotinylated BMPR-IA immobilized on a resin.
Application Notes
This antibody binds to human BMPR-1A, which, on ligand bindingg, forms a receptor complex acting as a serine/threonine kinase, activating SMAD transcriptional regulators. They positively regulate chondrocyte differentiation, for example. The antibody neutralizes BMP-binding to the receptor.
Antibody First Published
Harth et al. A selection fit mechanism in BMP receptor IA as a possible source for BMP ligand-receptor promiscuity. PLOS One 2010; 5(9)： e13049 PMID：20927405
Note on publication
Describes the generation of several anti BMPR-IA antibodies and subsequent crystallisation as well as binding studies.
Size
100 μg Purified antibody.
Concentration
1 mg/ml.
Purification
Protein A affinity purified
Buffer
PBS with 0.02% Proclin 300.
Storage Recommendation
Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at - 20⁰C.
