Cat. No.
MABL-493
Application
WB, ELISA, FC
Isotype
Engineer antibody
Species Reactivity
Human, Mouse
Clone No.
ham150-3.5
From
Recombinant Antibody
Specificity
The antibody is specific for BCL-3. B cell Lymphoma 3 is a member of the IkB subfamily of inhibitors. This subfamily is part of the NF-kB transcription factor protein family and it is suggested that a balance in the concentration of various NF-kB family members regulates apoptosis and survival of activated T cells.
Alternative Names
B-cell lymphoma 3 protein homolog
UniProt
Q9Z2F6
Immunogen
The original antibody was generated from a hamster immunized with mouse BCL-3.
Application Notes
The specificity of the original format of the antibody for mBcl-3 was confirmed by ELISA analysis. The antibody detected mBcl-3 and human Bcl-3 by western blot (Bassetti et al., 2009; PMID： 19208752).
Antibody First Published
Bassetti et al. Transgenic Bcl-3 slows T cell proliferation. Int Immunol. 2009 Apr; 21(4)： 339–348. PMID：19208752
Note on publication
The original paper describes the generation and characterization of the antibody.
Size
100 μg Purified antibody.
Concentration
1 mg/ml.
Purification
Protein A affinity purified
Buffer
PBS with 0.02% Proclin 300.
Storage Recommendation
Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at - 20⁰C.
