Cat. No.
MABL-369
Application
WB, ELISA, FC, IF
Isotype
Engineer antibody
Species Reactivity
Human
Clone No.
1G12
From
Recombinant Antibody
Specificity
This antibody specifically binds glycerol phosphate modifying group of human alpha dystroglycan. Alpha-dystroglycan (αDG) is an extracellular peripheral glycoprotein that acts as a receptor for extracellular matrix proteins containing laminin-G domains, and for certain adenoviruses. It is also a receptor for laminin-2 (LAMA2) and agrin in peripheral nerve Schwann cells and a receptor for laminin LAMA5. Defective glycosylation of alpha-dystroglycan is a biological marker for muscular dystrophy_x0002_dystroglycanopathy type A (MDDGA1), Walker-Warburg syndrome (WWS), muscle-eye-brain disease (MEB) and Fushan congenital muscle malnutrition (FCMD).
Alternative Names
Dystroglycan 1; Dag1; αDG; Alpha-DG; α-DAG; ALPHA DAG; Dystroglycan; Dystrophin-associated glycoprotein 1; A-Dystroglycan; A Dystroglycan; Alpha-dystroglycan; α dystroglycan; α-dystroglycan; 2-1G12-1-26
UniProt
Q62165
Immunogen
The original antibody was generated by immunizing BALB/c micewith recombinant human α_x0002_distroglycan.
Application Notes
The binding characterization of this antibody towards glycerol phosphate modifying group of alpha dystroglycan was done using ELISA. This antibody can recognize glycerol phosphate modifying group of alpha dystroglycan in an western blot and flow cytometric assay. This antibody can also be used for the immunofluorescence staining of colon cancer tissue (JP2022060048).
Antibody First Published
Note on publication
Size
100 μg Purified antibody.
Concentration
1 mg/ml.
Purification
Protein A affinity purified
Buffer
PBS with 0.02% Proclin 300.
Storage Recommendation
Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at - 20⁰C.
