Key features and details | |
Cat. No. | MABL-728 |
Name | Anti-CD151 mAbs |
Clone No. | AFD- 11G5a |
From | Recombinant Antibody |
Isotype | Engineer antibody |
Application | IP, WB, ELISA, FC, IF, IHC |
Species Reactivity | Human |
Basic Information | |
Specificity | This antibody binds to the CD151-integrin α3β1 binding site of the CD151 extracellular domain. |
Alternative Name | Tetraspanin-24; GP27; MER2; Platelet-endothelial tetraspan antigen 3; PETA-3; RAPH; SFA1; TSPAN24; Cluster of Differentiation 151 |
UniProt | P48509 |
Immunogen | This antibody was raised by immunizing mice. |
Application Notes | The antibody has been used in flow cytometry experiments and to assess the interaction of CD151 with integrins (Yauch 1998). CD151 can also regulate cell migration independent of integrins in cancer for tumour cell migration, and mAb 11G5a has been used for histologic detection of CD151 free in prostate cancer, which correlates with poor patient outcome (TD Palmer 2014). |
Antibody First Published | Yauch et al. Highly Stoichiometric, Stable, and Specific Association of Integrin α3β1 with CD151 Provides a Major Link to Phosphatidylinositol 4-Kinase, and May Regulate Cell Migration Mol Biol Cell. 1998 Oct; 9(10)： 2751–2765 PMID：9763442 |
Note on publication | Describes the Specific Association of Integrin α3β1 with CD151 and its link to cell migration |
COA Information （For reference only, actual COA shall prevail） | |
Size | 100 μg Purified antibody. |
Concentration | 1 mg/ml. |
Purification | Protein A affinity purified |
Buffer | PBS with 0.02% Proclin 300. |
Concentration | 1 mg/ml. |
Storage Recommendation | Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at - 20⁰C. |
