Anti-CD10 mAbs

Cat. No.

MABL-064

Name

Anti-CD10 mAbs

Clone No.

AFD-FR4D11

From

Recombinant Antibody

Isotype

Engineer antibody

Application

FC, IF, IHC

Species Reactivity

Human

Basic Information

Specificity

FR4D11 antibody recognizes CD10. It is a   cell surface enzyme with neutral metalloendopeptidase activity, which   inactivates a variety of biologically active peptides. CD10 is expressed on   the cells of lymphoblastic, Burkitt's, and follicular germinal center   lymphomas, and on cells from patients with chronic myelocytic leukemia (CML).

Alternative Name

Neprilysin; Atriopeptidase; Common acute   lymphocytic leukemia antigen; CALLA; Enkephalinase; Neutral endopeptidase 24.11; NEP; Neutral endopeptidase; Skin fibroblast elastase; SFE; EC 3.4.24;   EC 3.4.24.11; FR4D11/F3

UniProt

P08473

Immunogen

This antibody was raised by immunizing mice with Raji cells.

Application Notes

FR4D11 antibody can be used to identify and analyse neprilysin (CD10) via various techniques. For instance, it was utilized in the localization of neprilysin in human cerebral cortex via immunohistochemistry (Akiyama et al., 2001). This antibody was also used during a FACS analysis and phenotype characterization of Breast Cancer Stem Cells (BrCSCs) (Petrelli et al., 2015).

Antibody First Published

Akiyama et al. Immunohistochemical localization of neprilysin in the human cerebral cortex: inverse association with vulnerability to amyloid beta-protein (Abeta) deposition. Brain Res. 2001 Jun 1;902(2):277-81. PMID:11384622

Note on publication

This article characterizes the FR4D11 antibody and uses it in the immunohistochemical investigation of neprilysin in the brain tissue.

COA Information （For reference only, actual COA shall prevail）

Size

100 μg Purified antibody.

Concentration

1 mg/ml.

Purification

Protein A affinity purified

Buffer

PBS with 0.02% Proclin 300.

Concentration

1 mg/ml.

Storage Recommendation

Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at - 20⁰C.