Key features and details | |
Cat. No. | MABL-031 |
Name | Anti-Morphine mAbs |
Clone No. | AFD-12D4 |
From | Recombinant Antibody |
Isotype | Engineer antibody |
Application | WB, ELISA |
Species Reactivity | Species independent |
Basic Information | |
Specificity | The antibody binds to morphine with an affinity (Kd) of 46 nM. |
Alternative Name | Morphium; (5alpha,6alpha)-17-Methyl-7,8-didehydro-4,5- epoxymorphinan-3,6-diol |
UniProt | |
Immunogen | Morphine-6-hemisuccinate conjugated with BSA. |
Application Notes | The antibody binds specifically to morphine, an alkaloid opiate drug derived from the opium poppy administered for the management of narcotic pain. Morphine exerts its effects by binding to μ opiate receptors in the central nervous system and gastrointestinal tract, leading to analgesia and sedation, thereby increasing the patient's tolerance to pain. The monoclonal antibody 12D4 recognises the N-methyl to N-allyl substitution in the conversion of morphine to nalorphine. |
Antibody First Published | Glasel JA, Bradbury WM, Venn RF. Properties of murine anti-morphine antibodies. Mol Immunol. 1983 Dec;20(12):1419-22. PMID:6361525 |
Note on publication | Describes the isolation of four high affinity monoclonal antibodies against morphine. |
COA Information （For reference only, actual COA shall prevail） | |
Size | 100 μg Purified antibody. |
Concentration | 1 mg/ml. |
Purification | Protein A affinity purified |
Buffer | PBS with 0.02% Proclin 300. |
Concentration | 1 mg/ml. |
Storage Recommendation | Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at - 20⁰C. |
