Cat. No.
MABL-3718
Application
functional, ELISA
Isotype
Engineer antibody
Species Reactivity
RSV
Clone No.
RSHZ19 (Felvizumab)
From
Recombinant Antibody
Specificity
This antibody is specific for the an epitope located between amino acids 417-432 of conserved fusion (F) protein of RSV.
Alternative Names
SB 209763; respiratory syncytial virus
UniProt
Immunogen
This antibody was prepared by the humanization of an F protein-specific murine MAb, RSV19. More specifically, molecular techniques were used to insert the complementarity determining regions from murine RSV19 into a human IgG1 heavy and k light chain-variable domain framework.
Application Notes
Though shown to be safe and well-tolerated (Everitt, 1996) and protective against RSV infection in BALB/c mice and cotton rats (Wyde, 1995), this antibody did not demonstrate efficacy in a Phase 3 study (Reichert, 2008). In in vitro studies, palivizumab, another humanized Mab specific for the F protein of RSV, was 4 to 5-fold more potent than felvizumab in neutralising RSV (Scott, 1999).
Antibody First Published
Tempest et al. Reshaping a human monoclonal antibody to inhibit human respiratory syncytial virus infection in vivo. Biotechnology (N Y). 1991 Mar;9(3):266-71 PMID:1367535
Note on publication
Describes the original production of the humanized anti-RSV antibody from murine RSV19.
Size
100 μg Purified antibody.
Concentration
1 mg/ml.
Purification
Protein A affinity purified
Buffer
PBS with 0.02% Proclin 300.
Storage Recommendation
Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at - 20⁰C.
