Cat. No.
MABL-3712
Application
Block, FC
Isotype
Engineer antibody
Species Reactivity
Human
Clone No.
Natalizumab
From
Recombinant Antibody
Specificity
This antibody binds to the alpha 4 binds subunit of α4β1 (also known as very late antigen 4 [VLA-4] or CD49d-CD29) and α4β7 integrin
Alternative Names
CD49D; alpha 4 subunit of VLA-4 receptor; ITGA4; Integrin alpha-IV
UniProt
P13612
Immunogen
The RAMOS cell line, a non-EBV releasing cell line, injected into mice.
Application Notes
This antibody binds to human integrin alpha 4 and has been used to treat Multiple Sclerosis and Crohn's Disease.
Antibody First Published
Sheremata et al. A safety and pharmacokinetic study of intravenous natalizumab in patients with MS Neurology. 1999 Mar 23;52(5):1072-4. PMID:10102433
Note on publication
Describes the safety and pharmacokinetic characterization of this antibody in a clinical setting.
Size
100 μg Purified antibody.
Concentration
1 mg/ml.
Purification
Protein A affinity purified
Buffer
PBS with 0.02% Proclin 300.
Storage Recommendation
Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at - 20⁰C.
