Cat. No.
MABL-3680
Application
IP, Block, FC
Isotype
Engineer antibody
Species Reactivity
Human
Clone No.
YTH 906.9HL (Campath-6)
From
Recombinant Antibody
Specificity
Recognises low affinity interleukin 2 receptor alpha and medium-affinity interleukin 2 receptor beta.
Alternative Names
IL-2-RA; CD25; Interleukin-2 receptor subunit alpha; IL-2 receptor subunit alpha; IL-2R subunit alpha; IL2-RA; TAC antigen; p55; YTH906; YTH-906; CAMPATH-6
UniProt
P01589
Immunogen
Phytohemagglutinin activated human T lymphocytes.
Application Notes
This antibody binds to human and primate IL-2 receptor and prevents binding of IL2. The original rat IgG2b format had been evaluated for use in preventing transplant rejection.
Antibody First Published
Tighe et al. Delayed allograft rejection in primates treated with anti-IL-2 receptor monoclonal antibody Campath-6. Transplantation. 1988 Jan;45(1):226-8 PMID:3122385
Note on publication
Describes the generation of this antibody and the use of it in delaying allograft rejection in primates.
Size
100 μg Purified antibody.
Concentration
1 mg/ml.
Purification
Protein A affinity purified
Buffer
PBS with 0.02% Proclin 300.
Storage Recommendation
Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at - 20⁰C.
