Cat. No.
MABL-3678
Application
FC
Isotype
Engineer antibody
Species Reactivity
Human, Rhesus Monkey, Cynomolgus Monkey
Clone No.
10F381 (rituximab)
From
Recombinant Antibody
Specificity
CD20 (Human B-lymphocyte-restricted differentiation antigen, Bp35), is a hydrophobic transmembrane protein with a molecular weight of approximately 35 kDa located on pre-B and mature B lymphocytes, and most B-cell non-Hodgkin's lymphomas, but is not found on stem cells, pro-B cells, normal plasma cells or other normal tissues .
Alternative Names
Leu16; B-lymphocyte antigen CD20; B-lymphocyte surface antigen B1; Bp35 Leukocyte surface antigen Leu-16; Membrane-spanning 4-domains subfamily A member 1; CD20
UniProt
P11836
Immunogen
Human lymphoblastoid cell line SB.
Application Notes
Antibody First Published
Reff ME, Carner K, Chambers KS, Chinn PC, Leonard JE, Raab R, Newman RA, Hanna N, Anderson DR. Depletion of B cells in vivo by a chimeric mouse human monoclonal antibody to CD20. Blood. 1994 Jan 15;83(2):435-45. PMID:7506951
Note on publication
Describes the making of the chimeric murine anti-CD20 antibody 2B8 in conjunction with human kappa and IgG1 heavy-chain constant region sequences, and analysed using flow cytometry, in vivo pharmacology and animal systemic/tissue toxicity tests.
Size
100 μg Purified antibody.
Concentration
1 mg/ml.
Purification
Protein A affinity purified
Buffer
PBS with 0.02% Proclin 300.
Storage Recommendation
Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at - 20⁰C.
