Name
CDKN2C Human
Cat. No.
MAG-2938
Tag/Conjugates
His
Source
E.coli.
Shipped
Shipped with Ice Packs
Description
CDKN2C Human Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 192 amino acids (1-168 and having a molecular mass of 20.7kDa. CDKN2C is fused to a 24 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
Introduction
CDKN2C is a member of the CDKN2 cyclin-dependent kinase inhibitor family. CDKN2C cooperates with CDK4 or CDK6, and inhibits the activation of the CDK kinases, therefore acts as a cell growth regulator which regulates cell cycle G1 progression. CDKN2C suppresses the cell growth and proliferation with a correlated dependency on endogenous retinoblastoma protein RB. Studies in the knockout mice show CDKN2C takes part in regulating spermatogenesis, in addition to suppressing tumorigenesis.
Purification Method
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Physical Appearance
Sterile Filtered colorless solution.
Formulation
The CDKN2C solution (0.5mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 200mM NaCl, 2mM DTT and 10% glycerol.
Stability
Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Avoid multiple freeze-thaw cycles.
Purity
Greater than 95% as determined by SDS-PAGE.
Biological Activity
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Safety Data Sheet
SDS
Usage
Mabioway's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
Synonyms
Cyclin-dependent kinase inhibitor 2C (p18 inhibits CDK4), cyclin-dependent kinase 4 inhibitor C, cyclin-dependent kinase 6 inhibitor p18, INK4C, p18, p18-INK6, p18-INK4C, CDK6 inhibitor p18, cyclin-dependent inhibitor, CDKN6, p18-INK4c.
Amino acid sequence
MGSSHHHHHH SSGLVPRGSH MGSH MAEPWG NELASAAARG DLEQLTSLLQ NNVNVNAQNG FGRTALQVMK LGNPEIARRL LLRGANPDLK DRTGFAVIHD AARAGFLDTL QTLLEFQADV NIEDNEGNLP LHLAAKEGHL RVVEFLVKHT ASNVGHRNHK GDTACDLARL YGRNEVVSLM QANGAGGATN LQ
Background
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