Cat. No.
MABL-3707
Application
Block, FC
Isotype
Engineer antibody
Species Reactivity
Human, Rhesus Monkey, Cynomolgus Monkey
Clone No.
Daclizumab
From
Recombinant Antibody
Specificity
Binds to p55 chain of IL2R on human T cells, Tac antigen, which is expressed on T cells activated by mitogens, soluble antigens, and alloantigens but not on resting T cells, thymocytes, B cells, monocytes, activated B cells, leukemic T cell blasts from patients with acute lymphoblastic leukemia, and long-term T cell lines.
Alternative Names
CD25; Interleukin-2 receptor subunit alpha; IL-2 receptor subunit alpha; IL-2R subunit alpha; IL-2-RA; IL2-RA; TAC antigen; p55
UniProt
P01589
Immunogen
Cultured T-cells derived from a patient with Mycosis fungoides.
Application Notes
Antibody First Published
Queen C, Schneider WP, Selick HE, Payne PW, Landolfi NF, Duncan JF, Avdalovic NM, Levitt M, Junghans R, Waldmann TA. A humanized antibody that binds to the interleukin 2 receptor. Proc Natl Acad Sci U S A. 1989 Dec;86(24):10029-33. PMID:2513570
Note on publication
Describes the preparation the humanised mouse anti human Tac monoclonal antibody by combining the CDRs of the mouse anti- Tac antibody with human framework and constant regions and affinity characterisation.
Size
100 μg Purified antibody.
Concentration
1 mg/ml.
Purification
Protein A affinity purified
Buffer
PBS with 0.02% Proclin 300.
Storage Recommendation
Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at - 20⁰C.
