Cat. No.
MABL-3676
Application
Block, FC
Isotype
Engineer antibody
Species Reactivity
Human
Clone No.
hu1124 (Efalizumab)
From
Recombinant Antibody
Specificity
Binds to human LFA-1.
Alternative Names
LFA-1; integrin alpha L
UniProt
P20701
Immunogen
Efalizumab binds to CD11a, a subunit of leukocyte function antigen-1 (LFA-1), which is expressed on all leukocytes.
Application Notes
Efalizumab binds to the LFA-1 alpha I domain blocking the ICAM-1 binding site via steric hindrance.
Antibody First Published
Bauer et al. Population pharmacokinetics and pharmacodynamics of the anti-CD11a antibody hu1124 in human subjects with psoriasis. J Pharmacokinet Biopharm. 1999 Aug;27(4):397-420. PMID:10826130
Note on publication
Describes the analysis of the pharmacokinetics and pharmacodynamics of hu1124 [Efalizumab].
Size
100 μg Purified antibody.
Concentration
1 mg/ml.
Purification
Protein A affinity purified
Buffer
PBS with 0.02% Proclin 300.
Storage Recommendation
Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at - 20⁰C.
