Cat. No.
MABL-3667
Application
IP, Block, FC, IHC
Isotype
Engineer antibody
Species Reactivity
Mouse
Clone No.
MEL-14
From
Recombinant Antibody
Specificity
This antibody binds to mouse CD62L the mouse peripheral lymph node homing receptor, which is a lectin-like cell surface protein rapidly down-regulated upon cell activation with phorbol 12-myristate 13- acetate.
Alternative Names
L-selectin; LECAM-1; Ly-22; MEL14; Leu-8
UniProt
P18337
Immunogen
C3H/eb mouse B lymphoma 38C-13.
Application Notes
This antibody detects mouse CD62L and has been reported to inhibit the interaction of neutrophils with endothelial cells in vitro and inhibit the migration of neutrophils from the blood into sites of acute inflammation in the skin (Lewinsohn et al. 1987).
Antibody First Published
Lewinsohn, Bargatze & Butcher Leukocyte-endothelial cell recognition: evidence of a common molecular mechanism shared by neutrophils, lymphocytes, and other leukocytes. J Immunol. 1987 Jun 15;138(12):4313-21. PMID:3584977
Note on publication
Describes the generation of this
Size
100 μg Purified antibody.
Concentration
1 mg/ml.
Purification
Protein A affinity purified
Buffer
PBS with 0.02% Proclin 300.
Storage Recommendation
Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at - 20⁰C.
