Cat. No.
MABL-3391
Application
ELISA
Isotype
Engineer antibody
Species Reactivity
Human
Clone No.
AFD-W3759-cAb1
From
Recombinant Antibody
Specificity
This antibody binds an epitope between amino acid residues Ser112-Thr270 of the human IL-33. Interleukin 33 (IL-33). Interleukin 33 (IL-33) is a multifunctional cytokine which is constitutively expressed in structural cells such as smooth muscle cells, fibroblasts, mast cells, dendritic cells, macrophages, osteoblasts, epithelial cells, and endothelial cells. It is involved in the maturation of Th2 cells inducing the secretion of T-helper type 2-associated cytokines like IL-4, IL-5 and IL-13. It is also involved in activation of mast cells, basophils, eosinophils and natural killer cells. A study found that IL-33 is a bifunctional protein. On the one hand, IL-33 is localized in the nucleus and acts as a transcription factor; on the other hand, IL-33 is secreted outside the cell and acts as a cytokine by interacting with its receptor ST2.
Alternative Names
Interleukin-33; C9orf26; IL1F11; NFHEV; Interleukin-1 family member 11; IL-1F11; Nuclear factor from high endothelial venules; NF-HEV; W3759-cAb1-sz10-p1-xIgG4K.SP
UniProt
O95760
Immunogen
The original antibody was generated by using human IL-33 as an immunogen.
Application Notes
This antibody binds human IL-33 with a high binding affinity of 0.776 pM. The binding characterization of this antibody was done using ELISA and SPR (CN111620948).
Antibody First Published
Note on publication
Size
100 μg Purified antibody.
Concentration
1 mg/ml.
Purification
Protein A affinity purified
Buffer
PBS with 0.02% Proclin 300.
Storage Recommendation
Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at - 20⁰C.
