Key features and details | |
Cat. No. | MABL-3586 |
Name | Anti-MERS-CoV Spike Protein mabs [4c2](MABL-3586) |
Clone No. | 4c2 |
From | Recombinant Antibody |
Isotype | Engineer antibody |
Application | crystallization, NTRL, ELISA |
Species Reactivity | MERS-CoV |
Basic Information | |
Specificity | This antibody binds MERS-CoV spike protein at an epitope overlapping with the receptor- binding domain (MERS-RBD). |
Alternative Name | MERS-RBD; Middle East respiratory syndrome coronavirus spike |
UniProt | |
Immunogen | Recombinant spike receptor-binding domain of MERS-CoV prepared from insect High5 cells. |
Application Notes | This antibody binds to MERS-RBD and blocks virus entry in vitro with high efficacy by both steric hindrance and interface-residue competition. |
Antibody First Published | Li et al. A humanized neutralizing antibody against MERS-CoV targeting the receptor-binding domain of the spike protein Cell Research 25, 1237-1249 PMID:26391698 |
Note on publication | Describes the generation as well as functional and structural characterization of this antibody. |
COA Information （For reference only, actual COA shall prevail） | |
Size | 100 μg Purified antibody. |
Concentration | 1 mg/ml. |
Purification | Protein A affinity purified |
Buffer | PBS with 0.02% Proclin 300. |
Concentration | 1 mg/ml. |
Storage Recommendation | Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at - 20⁰C. |
