Cat. No.
MABL-3997
Application
IP, WB, ELISA, FC, IF, IHC-Fr
Isotype
Engineer antibody
Species Reactivity
Human
Clone No.
TA99
From
Recombinant Antibody
Specificity
Binds Tyrosinase-related protein-1 (TRP-1), a 70-75k enzyme located in melanocytes, which are specialized cells that produce a pigment called melanin, helping to stabilize tyrosinase, which is the enzyme responsible for the first step in melanin production and determine the shape of melanosomes, which are the structures in melanocytes where melanin is produced.
Alternative Names
Melanoma antigen gp75; 5,6-dihydroxyindole-2-carboxylic acid oxidase; DHICA oxidase; Catalase B; Glycoprotein 75; Tyrosinase-related protein 1; TRP; TRP-1; TRP1
UniProt
P17643
Immunogen
Tumour-associated glycoprotein 72 is a glycoprotein found on the surface of many cancer cells, including ovary, breast, colon, and pancreatic cells.
Application Notes
A In-111-labeled, murine version of this antibody was used in immunoscintigraphy to detect colorectal cancers in patients. In 16 % of patients, human-anti-mouse-responses developed.
Antibody First Published
Abdel-Nabi et al. In-111-labeled monoclonal antibody immunoscintigraphy in colorectal carcinoma: safety, sensitivity, and preliminary clinical results. Radiology PMID:2315476
Note on publication
Describes the use of this antibody in detection of colorectal cancers.
Size
100 μg Purified antibody.
Concentration
1 mg/ml.
Purification
Protein A affinity purified
Buffer
PBS with 0.02% Proclin 300.
Storage Recommendation
Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at - 20⁰C.
