Cat. No.
MABL-3936
Application
IB, ICC, WB, ELISA, IHC
Isotype
Engineer antibody
Species Reactivity
n/a
Clone No.
FU-MK-1
From
Recombinant Antibody
Specificity
Alternative Names
GA7332 TA; Tumour-associated antigen GA733-2
UniProt
Immunogen
The original mouse antibody was generated by immunizing BALB/c mice with human GDF-15 / MIC-1 protein. The humanized version was generated by grafting the variable domain regions of the original mouse antibody onto human framework regions.
Application Notes
This antibody can detect human GDF-15 protein in an ELISA and western blot. This antibody significantly reduces the neovascularization of endothelial cells produced by the GDF-15 protein. It also inhibits the growth of skin cancer, colon cancer, breast cancer or prostate cancer, pancreatic cancer, liver cancer, gastric cancer, inhibits angiogenesis inside/outside these tissues and inhibits the proliferation of cancer cells. The angiogenesis inhibitory activity was first confirmed in vitro through the tube formation assay and aortic ring branching assay. The inhibitory activity of this antibody was also tested in an in vivo angiogenesis assay using chick chorioallantoic membrane (CAM). It was reported that this antibody can inhibit angiogenesis in vivo to an excellent degree. This antibody is recommended for diagnosis of disease where GDF-15 is overexpressed (WO2019004550).
Antibody First Published
Note on publication
Size
100 μg Purified antibody.
Concentration
1 mg/ml.
Purification
Protein A affinity purified
Buffer
PBS with 0.02% Proclin 300.
Storage Recommendation
Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at - 20⁰C.
