Key features and details | |
Cat. No. | MABL-1357 |
Name | Anti-D-Dimer mAbs |
Clone No. | AFD- MA-15C5 |
From | Recombinant Antibody |
Isotype | Engineer antibody |
Application | ELISA, Imaging |
Species Reactivity | Human |
Basic Information | |
Specificity | This antibody is directed against a neoantigenic determinant expressed on the human fragment D-dimer. D-dimer is a protein fragment (small piece) that's made when a blood clot dissolves in your body. At D-dimer test is done to determine if a person has any blood clotting disorder. |
Alternative Name | XDP; Fragment D-dimer; Fibrin degradation fragment; Fibrin degradation product; Fibrin |
UniProt | P02671 |
Immunogen | The original antibody was generated by immunizing BALB/c mice with purified fragment D- dimer from cross linked human fibrin. |
Application Notes | This antibody has a 1000 fold higher affinity for binding human fragment D-dimer than for human fibrinogen. It could effectively bind D-dimer from human plasma clots and can be used for thrombus imaging in an animal model in vivo (PMID: 2749602). This antibody has been used in an ELISA assay for the quantification of fragment-D dimer in plasma (PMID: 3127914). |
Antibody First Published | Holvoet et al. Binding properties of monoclonal antibodies against human fragment D-dimer of cross-linked fibrin to human plasma clots in an in vivo model in rabbits. Thromb Haemost. 1989 Apr 25;61(2):307-13. PMID: 2749602 |
Note on publication | Describes the generation of two antibodies against human fragment D-dimer and determines their binding properties in an in vivo rabbit model. |
COA Information （For reference only, actual COA shall prevail） | |
Size | 100 μg Purified antibody. |
Concentration | 1 mg/ml. |
Purification | Protein A affinity purified |
Buffer | PBS with 0.02% Proclin 300. |
Concentration | 1 mg/ml. |
Storage Recommendation | Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at - 20⁰C. |
