Anti-Complement Receptor 1 & 2 mAbs

Cat. No.

MABL-1258

Name

Anti-Complement Receptor 1 & 2  mAbs

Clone No.

AFD- 7G6

From

Recombinant Antibody

Isotype

Engineer antibody

Application

CoStim, IP, WB, Block, FC, IHC-Fr

Species Reactivity

Mouse

Basic Information

Specificity

Recognises an epitope shared by 145-150kDa   and 190kDa complement receptor proteins, originally designated CR2 (CD21) and   CR1 (CD35).

Alternative Name

CD21 & CD35

UniProt

P19070 & P17927

Immunogen

Purified Mouse CR1.

Application Notes

This antibody binds mouse complement   receptors CR1 and CR2, functionally blocking CR2 leading to suppression of a   normal antibody immune response (see Heyman et al. 1990, PMID： 1695671)

Antibody First Published

Kinoshita et al. Monoclonal antibodies to mouse complement receptor type 1 (CR1). Their use in a distribution study   showing that mouse erythrocytes and platelets are CR1-negative. J Immunol. 1988 May 1;140(9)：3066-72 PMID: 2966205

Note on publication

Describes the generation and   characterization of this antibody.

COA Information （For reference only, actual COA shall prevail）

Size

100 μg Purified antibody.

Concentration

1 mg/ml.

Purification

Protein A affinity purified

Buffer

PBS with 0.02% Proclin 300.

Concentration

1 mg/ml.

Storage Recommendation

Store at 4⁰C for up to 3 months. For   longer storage, aliquot and store at - 20⁰C.